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Front Cover: Delaying Anticancer Drug Delivery by Self‐Assembly and Branching Effects of Minimalist Dendron–Drug Conjugates (Chem. Eur. J. 41/2019)
Author(s) -
Correard Florian,
Roy Myriam,
Terrasson Vincent,
Braguer Diane,
Estève MarieAnne,
Gingras Marc
Publication year - 2019
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201902437
Subject(s) - dendrimer , paclitaxel , conjugate , chemistry , drug delivery , branching (polymer chemistry) , peg ratio , intracellular , conjugated system , drug , combinatorial chemistry , biophysics , nanotechnology , pharmacology , biochemistry , materials science , cancer , medicine , organic chemistry , biology , mathematical analysis , mathematics , finance , economics , polymer
Self‐assembly of a covalently‐bound lipophilic drug to a dendron for making nanoparticles (Nps) is reported as a proof of concept in nanovectorization. A minimalist structural approach is shown with small PEG‐dendrons (yellow) conjugated to paclitaxel (PTX) which self‐assemble to Nps (beige Nps). They provide anticancer bioactivity (boxing glove) by significantly retarding and targeting intracellular delivery of PTX in 2D and 3D lung cancer cell cultures (red cells). A branching effect of dendrons is crucial, when compared to linear PTX conjugates. More information can be found in the Communication by M.‐A. Estève, M. Gingras, et al. on page 9586.