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Covalent versus Noncovalent Binding of Ruthenium η 6 ‐ p ‐Cymene Complexes to Zinc‐Finger Protein NCp7
Author(s) -
Sheng Yaping,
Hou Zhuanghao,
Cui Shiyong,
Cao Kaiming,
Yuan Siming,
Sun Mei,
Kljun Jakob,
Huang Guangming,
Turel Iztok,
Liu Yangzhong
Publication year - 2019
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201902434
Subject(s) - ruthenium , chemistry , non covalent interactions , covalent bond , zinc finger , protein–protein interaction , zinc , stereochemistry , combinatorial chemistry , molecule , biochemistry , organic chemistry , hydrogen bond , transcription factor , gene , catalysis
Ruthenium–arene complexes are a unique class of organometallic compounds that have been shown to have prominent therapeutic potencies. Here, we have investigated the interactions of Ru‐cymene complexes with a zinc‐finger protein NCp7, aiming to understand the effects of various ligands on the reaction. Five different binding modes were observed on selected Ru‐complexes. Ru‐cymene complex can bind to proteins through either noncovalent binding alone or through a combination of covalent and noncovalent binding modes. Moreover, the noncovalent interaction can promote the coordination of Ru II to NCp7, resulting synergistic effects of the different ligands. The binding of Ru(Cym) complexes leads to dysfunction of NCp7 through zinc‐ejection and structural perturbation. These results indicate that the reactivity of Ru‐complexes can be modulated by ligands through different approaches, which could be closely correlated to their different therapeutic effects.