Premium
“Turn‐On” Activatable AIE Dots for Tumor Hypoxia Imaging
Author(s) -
Xue Tianhao,
Jia Xiangqian,
Wang Jilei,
Xiang Jingyuan,
Wang Wei,
Du Juanjuan,
He Yaning
Publication year - 2019
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201902296
Subject(s) - fluorescence , förster resonance energy transfer , amphiphile , chemistry , fluorescence lifetime imaging microscopy , micelle , photochemistry , azobenzene , biophysics , aqueous solution , copolymer , polymer , optics , organic chemistry , physics , biology
A hypoxia‐responsive fluorescence probe of amphiphilic PEGylated azobenzene caged tetraphenylethene (TPE) for tumor cell imaging is reported; it possesses excellent solubility in aqueous medium due to the easy formation of micelles by self‐assembly. The fluorescence resonance energy transfer (FRET) process ensures that the fluorescence of the azobenene caged AIE fluorogen is quenched efficiently. When cultured with tumor cells, the azo‐bond is reduced under hypoxia conditions and the fluorescence of AIE fluorogen recovers dramatically. Besides using UV light, NIR light can also be used as the excited light resource to generate the fluorescence due to the two‐photon fluorescence imaging process.