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Targeting G‐Rich DNA Structures with Photoreactive Bis‐Cyclometallated Iridium(III) Complexes
Author(s) -
Weynand Justin,
Bonnet Hughes,
Loiseau Frédérique,
Ravanat JeanLuc,
Dejeu Jérôme,
Defrancq Eric,
Elias Benjamin
Publication year - 2019
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201902183
Subject(s) - iridium , guanine , circular dichroism , chemistry , surface plasmon resonance , dna , g quadruplex , ligand (biochemistry) , duplex (building) , photoinduced electron transfer , photochemistry , stereochemistry , crystallography , electron transfer , biochemistry , materials science , nucleotide , nanotechnology , receptor , nanoparticle , gene , catalysis
The synthesis and characterisation of three novel iridium(III) bis‐cyclometallated complexes is reported. Their photophysics have been fully characterised by classical methods and revealed charge‐transfer (CT) and ligand‐centred (LC) transitions. Their ability to selectively interact with G‐quadruplex telomeric DNA over duplex DNA has been studied by circular dichroism (CD), bio‐layer interferometry (BLI) and surface plasmon resonance (SPR) analyses. Interestingly, one of the complexes was able to promote photoinduced electron transfer (PET) with the guanine DNA base, which in turn led to oxidative damage (such as the formation of 8‐oxoguanine) to the telomeric sequence. To the best of our knowledge, this is the first study of highly photo‐oxidising bis‐cyclometallated iridium(III) complexes with G‐quadruplex telomeric DNA.