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Sequential Assembly of Mutually Interactive Supramolecular Hydrogels and Fabrication of Multi‐Domain Materials
Author(s) -
Piras Carmen C.,
Smith David K.
Publication year - 2019
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201902158
Subject(s) - self healing hydrogels , supramolecular chemistry , materials science , self assembly , component (thermodynamics) , nanotechnology , chemical engineering , chemistry , polymer chemistry , molecule , organic chemistry , physics , engineering , thermodynamics
A two‐component self‐sorting hydrogel based on acylhydrazide and carboxylic acid derivatives of 1,3:2,4‐dibenzylidene‐ d ‐sorbitol (DBS‐CONHNH 2 and DBS‐COOH) is reported. A heating–cooling cycle induces the self‐assembly of DBS‐CONHNH 2 , followed by the self‐assembly of DBS‐COOH induced by decreasing pH. Although the networks are formed sequentially, there is spectroscopic evidence of interactions between them, which impact on the mechanical properties and significantly enhance the ability of these low‐molecular‐weight gelators (LMWGs) to form gels when mixed. The DBS‐COOH network can be switched “off” and “on” within the two‐component gel through a pH change. By using a photo‐acid generator, the two‐component gel can be prepared combining the thermal trigger with photo‐irradiation. Photo‐patterned self‐assembly of DBS‐COOH within a pre‐formed DBS‐CONHNH 2 gel under a mask yields spatially controlled multi‐domain gels. Different gel domains can have different functions, for example, controlling the rate of release of heparin incorporated into the gel, or directing gold nanoparticle assembly. Such photo‐patterned multi‐component hydrogels have potential applications in regenerative medicine or bio‐nano‐electronics.