Premium
Cover Feature: Phosphonium‐Ring‐Fused Bicyclic Metallafuran Complexes of Ruthenium and Osmium (Chem. Eur. J. 39/2019)
Author(s) -
Yeung ChiFung,
Chung LaiHon,
Ng SzeWing,
Shek HauLam,
Tse SheungYing,
Chan SiuChung,
Tse ManKit,
Yiu ShekMan,
Wong ChunYuen
Publication year - 2019
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201902120
Subject(s) - phosphonium , ruthenium , osmium , chemistry , ring (chemistry) , ligand (biochemistry) , cisplatin , combinatorial chemistry , stereochemistry , medicinal chemistry , organic chemistry , receptor , biochemistry , biology , chemotherapy , genetics , catalysis
Reactions between terminal ynones and ruthenium(II)/osmium(II) precursors with a 1,1‐bis(diphenylphosphino)methane (dppm) auxiliary ligand produced metallafuran complexes with a fused five‐membered phosphonium ring. Kung Fu (literally means hard work in Cantonese) was spent on understanding their formation mechanism. These phosphonium‐containing metallafurans, like many phosphonium‐functionalized drugs, have the ability to induce mitochondrial dysfunction. They also exhibit stronger cytotoxicity against several human cancer cell lines in comparison with their metal precursors and the classic anticancer drug cisplatin. More information can be found in the Communication by C.‐Y. Wong et al. on page 9159.