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Crystal Structures of DOTMA Chelates from Ce 3+ to Yb 3+ : Evidence for a Continuum of Metal Ion Hydration States
Author(s) -
Woods Mark,
Payne Katherine M.,
Valente Edward J.,
Kucera Benjamin E.,
Young Victor G.
Publication year - 2019
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201902068
Subject(s) - ionic radius , square antiprism , lanthanide , chelation , crystallography , coordination sphere , ligand (biochemistry) , metal , chemistry , ion , molecule , metal ions in aqueous solution , coordination geometry , coordination number , paramagnetism , carboxylate , gadolinium , crystal structure , inorganic chemistry , hydrogen bond , stereochemistry , physics , biochemistry , receptor , organic chemistry , quantum mechanics
The crystal structures of chelates formed between each stable paramagnetic lanthanide ion and the octadentate polyamino carboxylate ligand DOTMA are described. A total of 23 individual chelates structures were obtained; in each chelate the coordination geometry around the metal ion is best described as a twisted square antiprism (torsion angle −25.0°–−31.4°). Despite the uniformity of the general coordination geometry provided by the DOTMA ligand, there is a considerable variation in the hydration state of each chelate. The early Ln 3+ chelates are associated with a single inner sphere water molecule; the Ln‐OH 2 interaction is remarkable for being very long. After a clear break at gadolinium, the number of chelates in the unit cell that have a water molecule interacting with the Ln 3+ decreases linearly until at Tm 3+ no water is found to interact with the metal ion. The Ln‐OH 2 distance observed in the chelates of the later Ln 3+ ions are also extremely long and increase as the ions contract (2.550–2.732 Å). No clear break between hydrated and dehydrated chelates is observed; rather this series of chelates appear to represent a continuum of hydration states in which the ligand gradually closes around the metal ion as its ionic radius decreases (with decreased hydration) and the metal drops down into the coordination cage.