Premium
Cover Feature: Lanthanum‐Catalyzed Enantioselective Trifluoromethylation by Using an Electrophilic Hypervalent Iodine Reagent (Chem. Eur. J. 35/2019)
Author(s) -
Granados Albert,
Rivilla Iván,
Cossío Fernando P.,
Vallribera Adelina
Publication year - 2019
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201902026
Subject(s) - hypervalent molecule , enantiopure drug , enantioselective synthesis , electrophile , trifluoromethylation , reagent , catalysis , chemistry , lanthanum , combinatorial chemistry , ligand (biochemistry) , iodine , medicinal chemistry , organic chemistry , alkyl , trifluoromethyl , biochemistry , receptor
La La Ligand ! Lanthanum(III) complexes incorporating enantiopure PyBOX ligands are suitable catalysts for the enantioselective trifluoromethylation of β‐oxo esters in the presence of hypervalent iodine Togni reagent. DFT calculations reveal that the enantioselectivity of the reaction stems from the rigid coordination pattern around the metallic center that results in the efficient blockage of one of the prochiral faces of the intermediate La III enolate. More information can be found in the Communication by F. P. Cossío, A. Vallribera, et al. on page 8214.