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Substitution of an Internal Disulfide Bridge with a Diselenide Enhances both Foldability and Stability of Human Insulin
Author(s) -
WeilKtorza Orit,
Rege Nischay,
Lansky Shifra,
Shalev Deborah E.,
Shoham Gil,
Weiss Michael A.,
Metanis Norman
Publication year - 2019
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201901974
Subject(s) - disulfide bond , diselenide , cover (algebra) , substitution (logic) , insulin , bridge (graph theory) , hebrew , chemistry , art , combinatorial chemistry , philosophy , biochemistry , classics , engineering , medicine , organic chemistry , linguistics , selenium , mechanical engineering
Invited for the cover of this issue are the groups of Norman Metanis at The Hebrew University of Jerusalem and Michael A. Weiss at the Indiana University School of Medicine. The image depicts a simple method for the preparation of new insulin analogues with a particular interest in more stable analogues with extended shelf life. Read the full text of the article at 10.1002/chem.201900892.