Premium
Cover Feature: Biphasic Enantioselective Fluorescent Recognition of Amino Acids by a Fluorophilic Probe (Chem. Eur. J. 33/2019)
Author(s) -
Zhu YuanYuan,
Wu XueDan,
Abed Mehdi,
Gu ShuangXi,
Pu Lin
Publication year - 2019
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201901864
Subject(s) - enantioselective synthesis , fluorescence , enantiomer , chemistry , amino acid , catalysis , phenylalanine , hydrolysis , combinatorial chemistry , organic chemistry , stereochemistry , biochemistry , physics , quantum mechanics
A fluorophilic fluorescent probe based on a perfluoroalkyl substituted bisbinaphthyl compound was designed and synthesized; it displayed a superpower of a highly enantioselective fluorescence response toward structurally diverse amino acids in a biphasic fluorous/aqueous system. This probe has been used to determine the enantiomeric composition of the crude phenylalanine products generated by an enzyme‐catalyzed asymmetric hydrolysis under various reaction conditions, showing the potential of this method in chiral catalyst screening. More information can be found in the Full Paper by S.‐X. Gu, L. Pu et al. on page 7866.