Chemo‐ and Regioselective Catalyst‐Controlled Carbocyclization of Alkynyl Ketones: Rapid Synthesis of 1‐Indanones and 1‐Naphthols | Zendy

Song Liangliang | Zendy; Tian Guilong | Zendy; Van der Eycken Erik V. | Zendy

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Chemo‐ and Regioselective Catalyst‐Controlled Carbocyclization of Alkynyl Ketones: Rapid Synthesis of 1‐Indanones and 1‐Naphthols

Author(s) -

Song Liangliang,

Tian Guilong,

Van der Eycken Erik V.

Publication year - 2019

Publication title -

chemistry – a european journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.687

H-Index - 242

eISSN - 1521-3765

pISSN - 0947-6539

DOI - 10.1002/chem.201901860

Subject(s) - regioselectivity , catalysis , dig , chemistry , intramolecular force , stereoselectivity , rhodium , aryl , combinatorial chemistry , medicinal chemistry , organic chemistry , computer science , alkyl , computer security

A catalyst‐controlled intramolecular carbocyclization of 2‐alkynyl aryl ketones is presented. Under rhodium(III) catalysis, 1‐indanones are formed through 5‐ exo ‐ dig carbocyclizations with exclusive chemo‐, regio‐ and stereoselectivity. When catalyzed by copper(I), 1‐naphthols are obtained through 6‐ endo ‐ dig carbocyclizations with exclusive chemo‐ and regioselectivity.

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