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Fluorine‐Containing Drugs Approved by the FDA in 2018
Author(s) -
Mei Haibo,
Han Jianlin,
Fustero Santos,
MedioSimon Mercedes,
Sedgwick Daniel M.,
Santi Claudio,
Ruzziconi Renzo,
Soloshonok Vadim A.
Publication year - 2019
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201901840
Subject(s) - food and drug administration , drug , approved drug , human immunodeficiency virus (hiv) , pharmacology , medicine , virology
Abstract Over the last two decades, fluorine substitution has become one of the essential structural traits in modern pharmaceuticals. Thus, about half of the most successful drugs (blockbuster drugs) contain fluorine atoms. In this review, we profile 17 fluorine‐containing drugs approved by the food and drug administration (FDA) in 2018. The newly approved pharmaceuticals feature several types of aromatic F and CF 3 , as well as aliphatic (CF 2 ) substitution, offering advances in the treatment of various diseases, including cancer, HIV, malarial and smallpox infections.