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Empowering Synthesis of Complex Natural Products
Author(s) -
Hernandez Lucas W.,
Sarlah David
Publication year - 2019
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201901808
Subject(s) - stereocenter , degree of unsaturation , task (project management) , computer science , natural (archaeology) , biochemical engineering , quality (philosophy) , overhead (engineering) , chemistry , engineering , organic chemistry , epistemology , systems engineering , biology , philosophy , paleontology , operating system , enantioselective synthesis , catalysis
Synthesis of natural products remains a daring task. Their richly diverse and intricate structures often encompass a large degree of unsaturation, contain fused and/or bridged rings, or possess numerous stereogenic centers. Thus, their preparation requires significant synthetic overhead, detracting from their overall practicality as well as hampering the ability of medicinal chemists to synthesize derivatives for pharmaceutical optimization and structure‐activity relationship studies. The purpose of this Minireview is to showcase recent examples of efficient total syntheses. Emphasis was not given to the evaluation of ideality or economies (quality), but rather to the practicality (quality with quantity).