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Antibody–Prodrug Conjugates with KSP Inhibitors and Legumain‐Mediated Metabolite Formation
Author(s) -
Lerchen HansGeorg,
StelteLudwig Beatrix,
Berndt Sandra,
Sommer Anette,
Dietz Lisa,
Rebstock AnneSophie,
Johannes Sarah,
Marx Leo,
Jörißen Hannah,
Mahlert Christoph,
Greven Simone
Publication year - 2019
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201901770
Subject(s) - prodrug , conjugate , cleavage (geology) , lysosome , chemistry , metabolite , peptide , biochemistry , stereochemistry , computer science , combinatorial chemistry , computational biology , enzyme , biology , mathematics , mathematical analysis , fracture (geology) , paleontology
Invited for the cover of this issue is the group of Hans‐Georg Lerchen and colleagues from Bayer AG R&D Pharmaceuticals. The image, provided by J. Franz and graphic designers from The New Atlantic (Cologne), depicts a cartoon representation of the legumain‐mediated cleavage of the peptide cap within the lysosome. Read the full text of the article at 10.1002/chem.201900441.