Antibody–Prodrug Conjugates with KSP Inhibitors and Legumain‐Mediated Metabolite Formation | Zendy

Lerchen HansGeorg | Zendy; StelteLudwig Beatrix | Zendy; Berndt Sandra | Zendy; Sommer Anette | Zendy; Dietz Lisa | Zendy; Rebstock AnneSophie | Zendy; Johannes Sarah | Zendy; Marx Leo | Zendy; Jörißen Hannah | Zendy; Mahlert Christoph | Zendy; Greven Simone | Zendy

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Antibody–Prodrug Conjugates with KSP Inhibitors and Legumain‐Mediated Metabolite Formation

Author(s) -

Lerchen HansGeorg,

StelteLudwig Beatrix,

Berndt Sandra,

Sommer Anette,

Dietz Lisa,

Rebstock AnneSophie,

Johannes Sarah,

Marx Leo,

Jörißen Hannah,

Mahlert Christoph,

Greven Simone

Publication year - 2019

Publication title -

chemistry – a european journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.687

H-Index - 242

eISSN - 1521-3765

pISSN - 0947-6539

DOI - 10.1002/chem.201901770

Subject(s) - prodrug , conjugate , cleavage (geology) , lysosome , chemistry , metabolite , peptide , biochemistry , stereochemistry , computer science , combinatorial chemistry , computational biology , enzyme , biology , mathematics , mathematical analysis , fracture (geology) , paleontology

Invited for the cover of this issue is the group of Hans‐Georg Lerchen and colleagues from Bayer AG R&D Pharmaceuticals. The image, provided by J. Franz and graphic designers from The New Atlantic (Cologne), depicts a cartoon representation of the legumain‐mediated cleavage of the peptide cap within the lysosome. Read the full text of the article at 10.1002/chem.201900441.

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