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Cover Feature: Decarboxylative Fluorination of 2‐Pyridylacetates (Chem. Eur. J. 31/2019)
Author(s) -
Kawanishi Ryouta,
Phongphane Lacksany,
Iwasa Seiji,
Shibatomi Kazutaka
Publication year - 2019
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201901546
Subject(s) - decarboxylation , electrophile , lithium (medication) , reagent , chemistry , catalysis , cover (algebra) , medicinal chemistry , organic chemistry , medicine , mechanical engineering , engineering , endocrinology
Under catalyst‐free conditions, decarboxylative fluorination of lithium 2‐pyridylacetates easily occurs. An electrophilic fluorinating reagent dramatically accelerates the decarboxylation of lithium 2‐pyridylacetates; this phenomenom has led to a one‐pot transformation of methyl 2‐pyridylacetates to 2‐(fluoroalkyl)pyridines via intermediate lithium 2‐pyridylacetates. The method has also been applied to the syntheses of 2‐(difluoroalkyl)pyridines. More information can be found in the Communication by K. Shibatomi, et al. on page 7453.