Premium
Ditocopheryl Sulfides and Disulfides: Synthesis and Antioxidant Profile
Author(s) -
Viglianisi Caterina,
Vasa Kristian,
Tanini Damiano,
Capperucci Antonella,
Amorati Riccardo,
Valgimigli Luca,
Baschieri Andrea,
Menichetti Stefano
Publication year - 2019
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201901537
Subject(s) - regioselectivity , antioxidant , sulfur , chemistry , ring (chemistry) , aryl , organic chemistry , catalysis , alkyl
Symmetrical ditocopheryl disulfides ( Toc ) 2 S 2 and symmetrical and unsymmetrical ditocopheryl sulfides ( Toc ) 2 S were simply prepared under remarkably mild conditions with complete control of the regiochemistry by using δ‐, γ‐, and β‐tocopheryl‐ N ‐thiophthalimides ( Toc‐NSPht ) as common starting materials. The roles of sulfur atom(s), H‐bond and aryl ring substitution pattern on the antioxidant profile of these new compounds, which were assembled by linking together two tocopheryl units, are also discussed.