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Front Cover: 1,3,9‐Triaza‐2‐oxophenoxazine: An Artificial Nucleobase Forming Highly Stable Self‐Base Pairs with Three Ag I Ions in a Duplex (Chem. Eur. J. 31/2019)
Author(s) -
Fujii Akane,
Nakagawa Osamu,
Kishimoto Yuki,
Okuda Takumi,
Nakatsuji Yusuke,
Nozaki Natsumi,
Kasahara Yuuya,
Obika Satoshi
Publication year - 2019
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201901481
Subject(s) - nucleobase , duplex (building) , metal ions in aqueous solution , dna , nucleic acid , ion , base pair , tap water , metal , chemistry , base (topology) , combinatorial chemistry , nanotechnology , materials science , organic chemistry , biochemistry , mathematics , engineering , mathematical analysis , environmental engineering
Metal‐mediated base pairs (MMBPs) are expected to have wide applications in attractive fields such as DNA nanodevices and metal ion sensors. This work reports an artificial nucleobase, 1,3,9‐triaza‐2‐oxophenoxazine (9‐TAP), that could be used to design metal ion architectures and improve the conductivity. Artificial nucleic acid with 9‐TAP was successfully synthesized and incorporated into oligodeoxyribonucleotides. As a result, self‐base pairs of 9‐TAP could form a highly stable MMBP with three Ag I ions in a DNA duplex. Furthermore, such a MMBP was very stable even with three consecutive modifications in the duplex. More information can be found in the Communication by O. Nakagawa, S. Obika, et al. on page 7443.