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Trifluoromethylation and Monofluoroalkenylation of Alkenes through Radical–Radical Cross‐Coupling
Author(s) -
Wang Qiang,
Qu Yi,
Tian Hao,
Liu Yuxiu,
Song Hongjian,
Wang Qingmin
Publication year - 2019
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201901349
Subject(s) - trifluoromethylation , chemistry , photochemistry , coupling (piping) , combinatorial chemistry , coupling reaction , redox , molecule , organic chemistry , materials science , catalysis , trifluoromethyl , alkyl , metallurgy
The first visible‐light‐induced trifluoromethylation and monofluoroalkenylation of simple alkenes via a challenging radical–radical cross‐coupling step was achieved. This method provided a mild, step‐economical and redox‐neutral route to privileged two different fluorinated difunctionalized allyl compounds. The utility of this method is illustrated by late‐stage modification of medically important molecules.