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Structure‐Pattern‐Based Total Synthesis
Author(s) -
Gerlinger Christa K. G.,
Gaich Tanja
Publication year - 2019
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201901308
Subject(s) - total synthesis , natural product , product (mathematics) , biochemical engineering , natural (archaeology) , computer science , artificial intelligence , chemistry , engineering , stereochemistry , mathematics , biology , paleontology , geometry
In this article the concept of structure‐pattern‐recognition and its application to total synthesis is summarized. By applying this synthetic strategy to the two biogenetically unrelated natural product families Sarpagine and Stemona alkaloids, a drastic increase of synthetic efficiency could be achieved. To highlight its potential, this strategy is compared with some elegant target‐oriented syntheses. The importance of strategic planning and synthesis design is clearly demonstrated.