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Directing‐Group‐Free C7‐Alkylations of N‐Alkylindoles Mediated by Cationic Zirconium Complexes: Role of Brønsted Acid for Catalytic Manifold
Author(s) -
Chen Ping,
Hao Yanhong,
Wang Xinxin,
Yuan Dan,
Yao Yingming,
Ackermann Lutz
Publication year - 2019
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201901268
Subject(s) - cationic polymerization , zirconium , brønsted–lowry acid–base theory , catalysis , alkyl , group (periodic table) , manifold (fluid mechanics) , chemistry , stereochemistry , organic chemistry , mechanical engineering , engineering
Highly position selective alkylations of N‐alkylindoles at C7‐positions have been enabled by cationic zirconium complexes. The strategy provides a straightforward access to install alkyl groups at C7‐positions of indoles without a complex directing group. Mechanistic studies provided support for the importance of Brønsted acids in the catalytic manifold.