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Front Cover: Unprecedented Diastereoselective Arylogous Michael Addition of Unactivated Phthalides (Chem. Eur. J. 29/2019)
Author(s) -
Sicignano Marina,
Schettini Rosaria,
Sica Luisa,
Pierri Giovanni,
De Riccardis Francesco,
Izzo Irene,
Maity Bholanath,
Minenkov Yury,
Cavallo Luigi,
Della Sala Giorgio
Publication year - 2019
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201901252
Subject(s) - front cover , phthalide , crown (dentistry) , cover (algebra) , michael reaction , art , front (military) , chemistry , art history , polymer science , stereochemistry , catalysis , materials science , organic chemistry , physics , engineering , composite material , mechanical engineering , meteorology
Crowned wedding : A highly diastereoselective arylogous Michael reaction of unactivated phthalides was achieved using catalytic amounts of KOH and 18‐crown‐6. DFT calculations of the transition state revealed the key role of the K + ⊂ crown complex in the syn‐diastereoselective coupling of phthalide ion and Michael acceptor, which, in the cover picture, are portrayed by Robin Hood and Maid Marian. In the drawing, which takes inspiration from a famous scene captured on the Nottingham Castle wall, King Richard the Lionheart, representing the crown complex at the top of the transition state, joins the hands of the lovers. More information can be found in the Full Paper by L. Cavallo, G. Della Sala, et al. on page 7131.