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Chemistry at High Dilution: Dinuclear 99 m Tc Complexes
Author(s) -
Bolliger Robin,
Frei Angelo,
Braband Henrik,
Meola Giuseppe,
Spingler Bernhard,
Alberto Roger
Publication year - 2019
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201901161
Subject(s) - chemistry , rhenium , dilution , bridging (networking) , medicinal chemistry , inorganic chemistry , computer network , physics , computer science , thermodynamics
The formation of di‐ or polynuclear complexes at nanomolar concentrations is generally too slow to be observed with 99m Tc. It is reported in this communication that an appropriate choice of potentially bridging ligands, herein thiols HS‐R, accelerates the dimerization reaction to an extent that dinuclear complexes are formed at very high dilution. The dinuclear nature of [ 99m Tc 2 (μ 2 ‐SR) 3 (CO) 6 ] − is shown by chromatographic comparison, not only with its rhenium homologue as commonly done, but also with the true 99 Tc analogue.