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Batch and Continuous‐Flow Iron(II)‐Catalyzed Synthesis of Sulfilimines and Sulfoximines using N ‐Mesyloxycarbamates
Author(s) -
Lai Calvine,
Mathieu Gary,
Gabrielli Tabarez Lucia Paola,
Lebel Hélène
Publication year - 2019
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201900953
Subject(s) - amination , catalysis , continuous flow , chemistry , combinatorial chemistry , homogeneous , hydrate , base (topology) , chemical engineering , organic chemistry , thermodynamics , mathematics , biochemical engineering , engineering , physics , mathematical analysis
The synthesis of sulfilimines and sulfoximines with N ‐mesyloxycarbamates in presence of catalytic iron(II) chloride hydrate is described. The use of 1‐butylimidazole as a base proved instrumental in enabling a homogeneous reaction mixture compatible with continuous flow processes. The amination is applicable to a wide range of substrates, and affords the desired product in good to excellent yields within 1 to 60 minutes.