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Front Cover: Catalytic Asymmetric Hydrogenation of Dehydroamino Acid Esters with Biscarbamate Protection and Its Application to the Synthesis of xCT Inhibitors (Chem. Eur. J. 20/2019)
Author(s) -
Yasuno Yoko,
Mizutani Iho,
Sueuchi Yuki,
Wakabayashi Yuuka,
Yasuo Nozomi,
Shimamoto Keiko,
Shinada Tetsuro
Publication year - 2019
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201900941
Subject(s) - chemistry , catalysis , amino acid , carbamate , asymmetric hydrogenation , cystine , combinatorial chemistry , front cover , organic chemistry , enantioselective synthesis , enzyme , biochemistry , cover (algebra) , mechanical engineering , cysteine , engineering
A new cystine‐glutamate exchanger inhibitor was created through the development of a new catalytic asymmetric synthesis method. Rh‐catalyzed catalytic asymmetric hydrogenation of dehydro amino acid esters was expanded to the synthesis of chiral amino acid esters with bis‐carbamate protection. The new chemistry was successfully applied to the synthesis of N ‐benzoyl diamino suberic acid, which showed potent inhibitory effects for cystine‐glutamate exchangers, a promising molecular target for cancer therapy. More information can be found in the Communication by T. Shinada et al. on page 5145.