Premium
A Three‐Color Fluorescent Supramolecular Nanoassembly of Phototherapeutics Activable by Two‐Photon Excitation with Near‐Infrared Light
Author(s) -
Fraix Aurore,
Kirejev Vladimir,
Malanga Milo,
Fenyvesi Éva,
Béni Szabolcs,
Ericson Marica B.,
Sortino Salvatore
Publication year - 2019
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201900917
Subject(s) - fluorescence , singlet oxygen , photosensitizer , supramolecular chemistry , photochemistry , two photon excitation microscopy , materials science , infrared , luminescence , excited state , chemistry , optoelectronics , optics , oxygen , molecule , organic chemistry , physics , nuclear physics
A supramolecular nanoassembly, of about 30 nm in diameter, that consists of a green‐fluorescent, β‐cyclodextrin‐based, branched polymer co‐encapsulating a red‐emitting singlet oxygen ( 1 O 2 ) photosensitizer and a nitric oxide (NO) photoreleaser, which comprises a blue fluorescent reporter, is here reported. The system exhibits “five‐in‐one” photofunctionalities. All components can be simultaneously excited in the phototherapeutic window with two‐photons by using near‐infrared light at 740 nm and despite their close proximity, behave as independent units. This allows for their in vitro visualization in carcinoma cancer cells, due to their distinct green, red, and blue fluorescence, and for the production of both cytotoxic 1 O 2 and biofunctional NO.