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Cover Feature: Ultrafast Single‐Scan 2D NMR Spectroscopic Detection of a PHIP‐Hyperpolarized Protease Inhibitor (Chem. Eur. J. 16/2019)
Author(s) -
Kiryutin Alexey S.,
Sauer Grit,
Tietze Daniel,
Brodrecht Martin,
Knecht Stephan,
Yurkovskaya Alexandra V.,
Ivanov Konstantin L.,
Avrutina Olga,
Kolmar Harald,
Buntkowsky Gerd
Publication year - 2019
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201900875
Subject(s) - chemistry , nuclear magnetic resonance spectroscopy , macromolecule , two dimensional nuclear magnetic resonance spectroscopy , spectroscopy , nuclear magnetic resonance , stereochemistry , biochemistry , physics , quantum mechanics
Two‐dimensional NMR spectroscopy is one of the most important spectroscopic tools for the investigation of biological macromolecules. Because of the low sensitivity of NMR it usually takes from several minutes to many hours to record such a spectrum. In this work, it is shown that a bioactive derivative of the sunflower trypsin inhibitor‐1 (SFTI‐1), a tetradecapeptide, can be detected by the combination of parahydrogen‐induced polarization (PHIP) and ultrafast 2D‐NMR spectroscopy in less than ten seconds. More information can be found in the Communication by G. Buntkowsky et al. on page 4025.