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Synthesis of Functionalized Ketones from Acid Chlorides and Organolithiums by Extremely Fast Micromixing
Author(s) -
Nagaki Aiichiro,
Sasatsuki Kengo,
Ishiuchi Satoshi,
Miuchi Nobuyuki,
Takumi Masahiro,
Yoshida Junichi
Publication year - 2019
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201900743
Subject(s) - micromixing , chemoselectivity , microreactor , electrophile , chemistry , combinatorial chemistry , mixing (physics) , functional group , organic chemistry , catalysis , polymer , analytical chemistry (journal) , physics , quantum mechanics
Synthesis of ketones containing various functional groups from acid chlorides bearing electrophilic functional groups and functionalized organolithiums was achieved using a flow microreactor system. Extremely fast mixing is important for high chemoselectivity.