Iridium(I)‐Catalyzed C−H Borylation in Air by Using Mechanochemistry | Zendy

Pang Yadong | Zendy; Ishiyama Tatsuo | Zendy; Kubota Koji | Zendy; Ito Hajime | Zendy

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Iridium(I)‐Catalyzed C−H Borylation in Air by Using Mechanochemistry

Author(s) -

Pang Yadong,

Ishiyama Tatsuo,

Kubota Koji,

Ito Hajime

Publication year - 2019

Publication title -

chemistry – a european journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.687

H-Index - 242

eISSN - 1521-3765

pISSN - 0947-6539

DOI - 10.1002/chem.201900685

Subject(s) - borylation , iridium , mechanochemistry , catalysis , chemistry , organic chemistry , alkyl , aryl

Mechanochemistry has been applied for the first time to an iridium(I)‐catalyzed C−H borylation reaction. By using either none or just a catalytic amount of a liquid, the mechanochemical C−H borylation of a series of heteroaromatic compounds proceeded in air to afford the corresponding arylboronates in good‐to‐excellent yields. A one‐pot mechanochemical C−H borylation/Suzuki–Miyaura cross‐coupling sequence for the direct synthesis of 2‐aryl indole derivatives is also described. The present study constitutes an important milestone towards the development of industrially attractive solvent‐free C−H bond functionalization processes in air.

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