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Stimuli‐Responsive DNA Self‐Assembly: From Principles to Applications
Author(s) -
Yu Yang,
Jin Bang,
Li Yulin,
Deng Zhaoxiang
Publication year - 2019
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201900491
Subject(s) - nanotechnology , dna , dna nanotechnology , computer science , computational biology , biology , materials science , genetics
Abstract Stimuli‐responsive DNA self‐assembly shares the advantages of both designed stimuli‐responsiveness and the molecular programmability of DNA structures, offering great opportunities for basic and applied research in dynamic DNA nanotechnology. In this minireview, we summarize the most recent progress in this rapidly developing field. The trigger mechanisms of the responsive DNA systems are first divided into six categories, which are then explained with illustrative examples following this classification. Subsequently, proof‐of‐concept applications in terms of biosensing, in vivo pH‐mapping, drug delivery, and therapy are discussed. Finally, we provide some remarks on the challenges and opportunities of this highly promising research direction in DNA nanotechnology.