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15 N MRI of SLIC‐SABRE Hyperpolarized 15 N‐Labelled Pyridine and Nicotinamide
Author(s) -
Svyatova Alexandra,
Skovpin Ivan V.,
Chukanov Nikita V.,
Kovtunov Kirill V.,
Chekmenev Eduard Y.,
Pravdivtsev Andrey N.,
Hövener JanBernd,
Koptyug Igor V.
Publication year - 2019
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201900430
Subject(s) - hyperpolarization (physics) , spin isomers of hydrogen , nuclear magnetic resonance , magnetic resonance imaging , spins , biomolecule , chemistry , physics , materials science , nuclear magnetic resonance spectroscopy , nanotechnology , medicine , organic chemistry , radiology , condensed matter physics , hydrogen
Magnetic Resonance Imaging (MRI) is a powerful non‐invasive diagnostic method extensively used in biomedical studies. A significant limitation of MRI is its relatively low signal‐to‐noise ratio, which can be increased by hyperpolarizing nuclear spins. One promising method is Signal Amplification By Reversible Exchange (SABRE), which employs parahydrogen as a source of hyperpolarization. Recent studies demonstrated the feasibility to improve MRI sensitivity with this hyperpolarization technique. Hyperpolarized 15 N nuclei in biomolecules can potentially retain their spin alignment for tens of minutes, providing an extended time window for the utilization of the hyperpolarized compounds. In this work, we demonstrate for the first time that radio‐frequency‐based SABRE hyperpolarization techniques can be used to obtain 15 N MRI of biomolecule 1‐ 15 N‐nicotinamide. Two image acquisition strategies were utilized and compared: Single Point Imaging (SPI) and Fast Low Angle SHot (FLASH). These methods demonstrated opportunities of high‐field SABRE for biomedical applications.