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Catalytic Asymmetric Hydrogenation of Dehydroamino Acid Esters with Biscarbamate Protection and Its Application to the Synthesis of xCT Inhibitors
Author(s) -
Yasuno Yoko,
Mizutani Iho,
Sueuchi Yuki,
Wakabayashi Yuuka,
Yasuo Nozomi,
Shimamoto Keiko,
Shinada Tetsuro
Publication year - 2019
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201900289
Subject(s) - catalysis , asymmetric hydrogenation , combinatorial chemistry , chemistry , enantioselective synthesis , organic chemistry
Catalytic asymmetric hydrogenation of dehydroamino acid esters with biscarbamate protection was examined for the first time to prepare optically active amino acids. The new method was successfully applied to the synthesis of new cystine–glutamate exchanger inhibitors.