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Frontispiece: Newly Synthesized Lipid–Porphyrin Conjugates: Evaluation of Their Self‐Assembling Properties, Their Miscibility with Phospholipids and Their Photodynamic Activity In Vitro
Author(s) -
Massiot Julien,
Rosilio Véronique,
Ibrahim Nada,
Yamamoto Akihisa,
Nicolas Valérie,
Konovalov Oleg,
Tanaka Motomu,
Makky Ali
Publication year - 2018
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201887265
Subject(s) - porphyrin , photodynamic therapy , conjugate , chemistry , in vitro , combinatorial chemistry , miscibility , liposome , pheophorbide a , supramolecular chemistry , biophysics , materials science , biochemistry , organic chemistry , molecule , biology , mathematical analysis , mathematics , polymer
Lipid–porphyrin conjugates are considered as promising building blocks for supramolecular structures with multifunctional properties such as those required for anticancer photodynamic therapy. The Full Paper by A. Makky et al. on page 19179 ff. describes the synthesis of two new lipid‐porphyrin conjugates by coupling chlorophyll‐a derivative, pheophorbide‐a, to natural phospholipids. These conjugates exhibited self‐assembling properties, high loading rate in liposomes membranes, interesting optical behavior and promising photodynamic activity with better selectivity in vitro to esophageal squamous cell carcinoma relative to normal cells.