Premium
Frontispiece: Chemical Synthesis of Bioactive Naturally Derived Cyclic Peptides Containing Ene‐Like Rigidifying Motifs
Author(s) -
De Leon Rodriguez Luis M.,
Williams Elyse T.,
Brimble Margaret A.
Publication year - 2018
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201886862
Subject(s) - cyclic peptide , peptide , chemistry , stereochemistry , computational biology , combinatorial chemistry , biology , biochemistry
There has been a growing interest to develop chemical approaches for the synthesis of highly constrained, naturally derived cyclopeptides. It is known that structural rigidity correlates with the specificity, bioactivity, and stability of these peptide systems, thus rigid systems are particularly attractive leads for development of potent biopharmaceuticals. Recent advances have provided excellent new strategies to overcome the challenges involved, broadening the repertoire of available methodology. For more information, see the Minireview by M. A. Brimble et al. on page 17869 ff.