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Frontispiece: Advances in Native Chemical Ligation–Desulfurization: A Powerful Strategy for Peptide and Protein Synthesis
Author(s) -
Jin Kang,
Li Xuechen
Publication year - 2018
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201886662
Subject(s) - native chemical ligation , peptide , cysteine , residue (chemistry) , chemical ligation , chemistry , ligation , alanine , thioester , side chain , amino acid , combinatorial chemistry , stereochemistry , biochemistry , organic chemistry , biology , microbiology and biotechnology , enzyme , polymer
A side‐chain unprotected peptide with C‐terminal thioesters can chemoselectively react with another side‐chain unprotected peptide carrying an N‐terminal cysteine residue to afford the ligated peptide generating the Xaa‐Cys linkage at the conjunction site (where Xaa is any amino acid). Advancements of chemoselective desulfurization methods have enabled converting the cysteine residue of the ligation product into alanine, thus expanding the repertoire of native chemical ligation. For a full discussion see the Concept article by K. Jin and X. Li on page 17397 ff.