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Frontispiece: Emerging Applications of Fluorogenic and Non‐fluorogenic Bifunctional Linkers
Author(s) -
Liu Guhuan,
Hu Jinming,
Liu Shiyong
Publication year - 2018
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201886263
Subject(s) - bifunctional , covalent bond , chemistry , combinatorial chemistry , in situ , nanotechnology , in vivo , biophysics , biochemistry , materials science , biology , organic chemistry , catalysis , microbiology and biotechnology
Bifunctional linkers greatly facilitate the covalent conjugation of peptides, proteins, and DNA with drugs, imaging probes, contrast agents, and synthetic polymers. Compared to conventional non‐fluorogenic linkers, bifunctional fluorogenic linkers allow for in situ monitoring the occurrence and extent of conjugation process under both in vitro and in vivo levels. In their Review article on page 16484 ff., S. Liu et al. discuss recent progress in this area and mainly focus on emerging concepts relevant to fluorogenic linkers, including double‐caging fluorogenic linkers and functional linkers with self‐immolative motifs.