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Frontispiece: Chemical Kinetics of Radiolabelling Reactions
Author(s) -
Holland Jason P.
Publication year - 2018
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201886262
Subject(s) - kinetics , chemistry , chemical kinetics , combinatorial chemistry , raclopride , radiochemistry , computational chemistry , biochemistry , physics , quantum mechanics , receptor , antagonist
Chemical kinetics is one of the most powerful tools available for investigating reaction mechanisms, but is rarely applied in radiopharmaceutical sciences. The Concept article by J. P. Holland on page 16472 ff. introduces the theoretical basis of radiochemical kinetics and illustrates how kinetic modelling can be used to aid in the design, discovery and optimisation of radiolabelling reactions for the synthesis of positron‐emitting radiopharmaceuticals. Examples show kinetic simulations of complex reaction mixtures including the synthesis of a diverse range of clinical grade radiopharmaceuticals like [ 11 C]raclopride, 2‐deoxy‐2‐[ 18 F]fluoro‐ d ‐glucose ([ 18 F]FDG), [ 68 Ga]GaPSMA‐11, and the antibody‐based agent [ 89 Zr]Zr‐DFO‐J591.