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Frontispiece: Cell‐Surface Engineering for Advanced Cell Therapy
Author(s) -
Lee Jungkyu K.,
Choi Insung S.,
Oh Tong In,
Lee EunAh
Publication year - 2018
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201885963
Subject(s) - anoikis , extracellular matrix , microbiology and biotechnology , cell , intracellular , signal transduction , multicellular organism , extracellular , cell signaling , programmed cell death , chemistry , biology , apoptosis , biochemistry
Cell–ECM interactions (ECM=extracellular matrix) can keep the cells alive through the activation of intracellular survival signaling pathways. When cells are detached from ECM stroma, the cells enter an attachment‐deprived state, which is devoid of extracellular signals that trigger the activation of survival signaling pathways. Therefore, single cells in the detached state eventually undergo anoikis, a type of cell death induced by an attachment‐deprived state. Cell encapsulation can provide a signaling que for the cells in an attachment‐deprived state to activate survival signaling pathways. Depending on the purpose of application, cells are encapsulated in their single‐cellular or multicellular states. The Minireview by E. Lee et al. on page 15725 ff. summarizes the current research strategies of cell encapsulation in the perspective for future applications.