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Frontispiece: Therapeutic Nanoreactors as In Vivo Nanoplatforms for Cancer Therapy
Author(s) -
Mukerabigwi Jean Felix,
Ge Zhishen,
Kataoka Kazunori
Publication year - 2018
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201885962
Subject(s) - nanoreactor , in vivo , systemic circulation , cancer therapy , cancer research , cancer , chemistry , nanotechnology , medicine , materials science , pharmacology , biology , nanoparticle , microbiology and biotechnology
An ideal therapeutic nanoreactor designed for cancer therapy is characterized by the ability to efficiently protect immobilized active materials during systemic circulation, selectively accumulate and respond to the tumor microenvironment, and able to allow selective diffusion of reactant and products across its reaction‐vessel membrane. Thereby its structure integrity is maintained for in situ conversion of inert/less toxic reactants into toxic products as anticancer drugs or substances that can efficaciously eradicate tumor cells with remarkable minimized unwanted systemic toxicities. For more information see the Minireview by K. Kataoka et al. on page 15706 ff.