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Frontispiece: Progress in Lanthionine and Protected Lanthionine Synthesis
Author(s) -
Denoël Thibaut,
Lemaire Christian,
Luxen André
Publication year - 2018
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201885862
Subject(s) - lanthionine , lantibiotics , cystine , chemistry , combinatorial chemistry , peptide , biochemistry , nisin , organic chemistry , cysteine , enzyme , antimicrobial
Despite its simple looking structure , the synthesis of lanthionine, the monosulfide analogue of cystine, is by no means trivial. The interesting pharmacological effect of lanthipeptides, peptides containing a lanthionine or a β‐Me‐lanthionine, has persuaded the synthetic organic chemists to develop new approaches avoiding the various side reactions (e.g. racemisation, elimination, transposition, hydrolysis) that impede lanthionine preparation. In their Review article on page 15421 ff., T. Denoël et al. summarize the known synthetic routes leading to protected and unprotected lanthionine, providing several useful practical details. One example of lantibiotic synthesis and a well‐structured, self‐explanatory conclusion are also presented.