Premium
Frontispiece: Microfluidic Devices in the Fast‐Growing Domain of Single‐Cell Analysis
Author(s) -
Khan Mashooq,
Mao Sifeng,
Li Weiwei,
Lin JinMing
Publication year - 2018
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201885861
Subject(s) - microfluidics , single cell analysis , microfluidic chip , epigenetics , nanotechnology , computer science , computational biology , cell , chemistry , materials science , biology , biochemistry , gene
In microfluidic based single‐cell analysis , every step from tissue dissociation to single‐cell analysis is important. The human tissue is a complex system and isolation of a large number of targeted cells is required for accurate analysis. Therefore, the development of high‐throughput microfluidic devices is necessary. The microfluidic devices provide an easy platform to be integrated with microscopy, spectrometry, and other ultrasensitive technique for on‐chip and off‐chip analysis. At the present microfluidic devices enable the analysis of only one type of molecules from single cells, which leads to incomplete information. Besides, every type of cells has distinct epigenetic characteristics therefore, the role of epigenetic regulations is crucial in the processes of disease development. Therefore, advancement in microfluidic based single‐cell analysis for multi‐omics approaches is necessary to empower comprehensive and simultaneous studies of different types of molecules and evaluation of epigenetic characteristics. For more details, see the Review by J.‐M. Lin et al. on page 15398 ff.