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Frontispiece: Sequence‐Selective Recognition of Peptides in Aqueous Solution: A Supramolecular Approach through Micellar Imprinting
Author(s) -
Zhao Yan
Publication year - 2018
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201885362
Subject(s) - supramolecular chemistry , peptide , molecular recognition , bioorganic chemistry , imprinting (psychology) , molecular imprinting , sequence (biology) , aqueous solution , micelle , peptide sequence , chemistry , combinatorial chemistry , amino acid , biochemistry , organic chemistry , molecule , selectivity , gene , catalysis , enzyme
Sequence‐selective binding of peptides is a highly important and yet elusive goal in supramolecular and bioorganic chemistry. Complex functional groups on a peptide and subtle structural differences among closely related amino acids makes the molecular recognition particularly challenging. A newly developed concept of micellar imprinting encodes cross‐linked micelles with hydrophobic “dimples” and polar binding functionalities to interact with the peptide template in a strong and selective manner, providing a unique solution to the long‐standing problem. For more information see the Concept article by Y. Zhao on page 14001 ff.