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Frontispiece: Luminescence from Lanthanide(III) Ions Bound to the Glycocalyx of Chinese Hamster Ovary Cells
Author(s) -
ArppeTabbara Riikka,
CarroTemboury Miguel R.,
Hempel Casper,
Vosch Tom,
Sørensen Thomas Just
Publication year - 2018
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201884667
Subject(s) - glycobiology , lanthanide , luminescence , chinese hamster ovary cell , chemistry , function (biology) , glycocalyx , luminescent measurements , biochemistry , ion , nanotechnology , biophysics , biology , materials science , microbiology and biotechnology , organic chemistry , glycoprotein , glycan , optoelectronics , receptor
The imaging of subcellular structures is essential in all areas of life science and research progress with the development of new imaging and analysis methods. New analytic methods have fueled the rise of glycobiology, showing that sugars are as important for biological function as proteins. Lanthanide luminescence‐based contrast agents are highly relevant as they allow for extreme sensitivity in assays with background free images. We show that the unique coordination chemistry of lanthanide ions can be used to selectively label and image specific sugars. For more information, see the Communication by T. Vosch, T. J. Sørensen et al. on page 11885 ff.