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Frontispiece: Gold(III) Complexes for Antitumor Applications: An Overview
Author(s) -
Bertrand Benoît,
Williams Morwen R. M.,
Bochmann Manfred
Publication year - 2018
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201884663
Subject(s) - chemistry , intracellular , combinatorial chemistry , gold compounds , cisplatin , nanotechnology , vectorization (mathematics) , platinum , biophysics , mechanism of action , biochemistry , in vitro , materials science , biology , computer science , catalysis , chemotherapy , parallel computing , genetics
Starting from cisplatin , the isoelectronic gold(III) complexes have been investigated for their potential anticancer properties. In recent years tremendous progress has been made into the design of stable gold(III) complexes, enabling the study of their mechanism of action including interactions with potential biological targets and intracellular uptake and localization. This revealed that gold complexes interact with cellular targets very differently from platinum, via inhibition of enzymes rather than interaction with DNA. Moreover, the development of stable gold(III) scaffolds opened the way to the synthesis of bioconjugates for the vectorization and selective delivery of gold(III)‐based antiproliferative agents. For more details, see the Review by B. Bertrand, M. R. M. Williams, and M. Bochmann on page 11840 ff.