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Frontispiece: Expanding the Rubterolone Family: Intrinsic Reactivity and Directed Diversification of PKS‐derived Pyrans
Author(s) -
Guo Huijuan,
Benndorf René,
König Stefanie,
Leichnitz Daniel,
Weigel Christiane,
Peschel Gundela,
Berthel Patrick,
Kaiser Marcel,
Steinbeck Christoph,
Werz Oliver,
Poulsen Michael,
Beemelmanns Christine
Publication year - 2018
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201884465
Subject(s) - moiety , pyran , chemistry , reactivity (psychology) , stereochemistry , pyridine , click chemistry , combinatorial chemistry , organic chemistry , medicine , alternative medicine , pathology
Rubterolones are highly substituted tropolone alkaloids containing a rearranged PKS core structure, a sugar moiety and a pyridine ring. Two key biosynthetic precursors that contain a highly reactive pyran moiety have been described. Their intrinsic reactivity was investigated yielding several new rubterolone derivatives, two of which contained a unique thiazolidine moiety. Three rubterolone derivatives were chemically modified with fluorescence and biotin tags using peptide coupling and click reaction. For more information, see the Full Paper by C. Beemelmanns et al. on page 11319 ff.