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Frontispiece: Insulin Hexamer‐Caged Gadolinium Ion as MRI Contrast‐o‐phore
Author(s) -
Taylor Steven K.,
Tran Timothy H.,
Liu Michael Z.,
Harris Paul E.,
Sun Yanping,
Jambawalikar Sachin R.,
Tong Liang,
Stojanovic Milan N.
Publication year - 2018
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201884265
Subject(s) - random hexamer , gadolinium , contrast (vision) , ion , chemistry , crystallography , nuclear magnetic resonance , physics , optics , organic chemistry
Gadolinium ions can be caged within the water‐filled central cavity of insulin hexamers. These stable assemblies possess very high relaxivities as MRI contrast agents ‐ twenty times more sensitive than clinical macrocycle‐based CAs. Hexamer‐binding ligands can be used to allosterically modulate this contrast‐o‐phore. For more information, see the Full Paper by S. K. Taylor, L. Tong, M. N. Stojanovic et al. on page 10646 ff.