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Frontispiece: 2‐Benzoylpyridine Ligand Complexation with Gold Critical for Propargyl Ester‐Based Protein Labeling
Author(s) -
Lin Yixuan,
Vong Kenward,
Matsuoka Koji,
Tanaka Katsunori
Publication year - 2018
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201884264
Subject(s) - propargyl , combinatorial chemistry , chemistry , in vivo , aryl , ligand (biochemistry) , catalysis , anticancer drug , stereochemistry , drug , pharmacology , biochemistry , receptor , organic chemistry , medicine , biology , alkyl , microbiology and biotechnology
A gold(III) catalyst and propargyl esters undergo the first example of aryl–alkynyl cross‐coupling in live mice. Coupled with the continued development of organ‐targeting, metal‐carrier glycoalbumins, this work will undeniably aid the development of “Therapeutic In Vivo Synthetic Chemistry”. This is a promising therapeutic strategy, with potential focus on anticancer drug synthesis on targeted diseases (e.g., tumors) through metal‐catalyzed C−C bond formation. For more information, see the Communication by K. Tanaka et al. on page 10595 ff.