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Frontispiece: The Physico‐Chemical Basis of DNA Radiosensitization: Implications for Cancer Radiation Therapy
Author(s) -
Schürmann Robin,
Vogel Stefanie,
Ebel Kenny,
Bald Ilko
Publication year - 2018
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201884161
Subject(s) - dna , dna damage , reactivity (psychology) , electron , chemistry , biophysics , cancer , nanotechnology , radiochemistry , materials science , biochemistry , physics , biology , medicine , genetics , pathology , alternative medicine , quantum mechanics
The concept of physico‐chemical radiosensitization is based on the enhanced reactivity of DNA towards secondary low‐energy electrons, or the increase of local concentration of such electrons. This can for example be achieved by incorporation of halogenated nucleosides into DNA, or by administration of metal nanoparticles. In their Concept article on page 10271 ff., I. Bald et al. discuss the fundamental mechanisms of low‐energy electron‐induced DNA damage and present the recent experimental advancements in the quantification of DNA strand breaks in chemically modified DNA.