Premium
Frontispiece: Organometallic Conjugates of the Drug Sulfadoxine for Combatting Antimicrobial Resistance
Author(s) -
Chellan Prinessa,
Avery Vicky M.,
Duffy Sandra,
Triccas James A.,
Nagalingam Gayathri,
Tam Christina,
Cheng Luisa W.,
Liu Jenny,
Land Kirkwood M.,
Clarkson Guy J.,
RomeroCanelón Isolda,
Sadler Peter J.
Publication year - 2018
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201884064
Subject(s) - antimicrobial , sulfadoxine , drug resistance , malaria , drug , chemistry , traditional medicine , plasmodium falciparum , microbiology and biotechnology , pharmacology , biology , medicine , pyrimethamine , immunology
Growing resistance to antimicrobial drugs is an urgent life‐threatening problem, forcing medicinal chemists to redesign current drug scaffolds. Derivatization of known drugs to circumvent microbial resistance mechanisms is now an established strategy. The international UK, South African, Australian and USA collaboration of P. Chellan, P. J. Sadler et al. reported in the Full Paper on page 10078 ff., shows that organometallic conjugation of the antibacterial drug sulfadoxine has a remarkable effect on activity. Sulfadoxine has little activity towards various microbial strains, including Plasmodium falciparum and Mycobacterium tuberculosis , but introduction of half‐sandwich rhodium and iridium fragments dramatically “switched on” activity, so providing new drug leads to fight resistance.