Premium
Frontispiece: High Throughput Experimentation and Continuous Flow Validation of Suzuki–Miyaura Cross‐Coupling Reactions
Author(s) -
Jaman Zinia,
Mufti Ahmed,
Sah Samyukta,
Avramova Larisa,
Thompson David H.
Publication year - 2018
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201883865
Subject(s) - throughput , continuous flow , microfluidics , microtiter plate , coupling (piping) , coupling reaction , flow (mathematics) , computer science , chemistry , reaction conditions , combinatorial chemistry , process engineering , catalysis , nanotechnology , biochemical engineering , chromatography , materials science , organic chemistry , mechanics , engineering , physics , telecommunications , wireless , metallurgy
A rapid method for testing reaction conditions suitable for executing Suzuki‐Miyaura reactions is described. The optimal conditions discovered by microtiter batch experiments were found to translate well to continuous flow conditions using a microfluidic reactor for the synthesis of nine different hydroxybiphenyl intermediates. For more information, see the Full Paper by D. H. Thompson et al. on page 9546 ff.