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Frontispiece: Synthesis of Highly Substituted 1,2‐Diazetidin‐3‐ones, Small‐Ring Scaffolds for Drug Discovery
Author(s) -
Santos Marilia S.,
Nortcliffe Andrew,
Lewis William,
Bradshaw Tracey D.,
Moody Christopher J.
Publication year - 2018
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201883365
Subject(s) - ring (chemistry) , chemical space , curse of dimensionality , drug discovery , moment of inertia , rocket (weapon) , range (aeronautics) , inertia , space (punctuation) , nanotechnology , crystallography , materials science , chemistry , physics , computer science , engineering , aerospace engineering , artificial intelligence , organic chemistry , classical mechanics , composite material , biochemistry , operating system
1,2‐Diazetidin‐3‐ones remain an under‐investigated small‐ring heterocycle. Nevertheless their diverse structures offer the potential to explore chemical space as illustrated by the principal moments of inertia “triangle” in rod‐like (rocket), sphere‐like (planet) and disc‐like (flying saucer) regions. Inspired by the unexpected three‐dimensionality of substituted 1,2‐diazetidin‐3‐ones, the synthesis and functionalization of a range of these strained four‐membered rings are reported; for more details, see Full Paper by C. J. Moody et al. on page 8325 ff.